The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
Identifieur interne : 000507 ( Main/Exploration ); précédent : 000506; suivant : 000508The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
Auteurs : Mark R. Cookson [États-Unis]Source :
- Nature Reviews Neuroscience [ 1471-003X ] ; 2010-12.
Abstract
Parkinson's disease, like many common age-related conditions, is now recognized to have a substantial genetic component. Here, I discuss how mutations in a large complex gene — leucine-rich repeat kinase 2 (LRRK2) — affect protein function, and I review recent evidence that LRRK2 mutations affect pathways that involve other proteins that have been implicated in Parkinson's disease, specifically α-synuclein and tau. These concepts can be used to understand disease processes and to develop therapeutic opportunities for the treatment of Parkinson's disease.
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DOI: 10.1038/nrn2935
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